ABSTRACT
The field of nanomedicine has been developed to achieve enhanced and targeted delivery of biomolecules including nanoparticles. Despitetheir convenience, metal nanoparticles confront strenuous challenges including toxicity, low translocation ability into cells and clearancefrom the organs. This study aims to detect the in vivo cellular interaction between prostatic tissues and gold nanorods on the prostatic tissueand to detect the short-term effect of the gold nanorods to reach prostatic tissue by histopathologic and electron microscopic examinations.Forty-eight adult male albino rats (180-200 g) were used. They were divided into 2 equal groups. The 1st group received injection of saline0.9% (i.P); while, the 2nd group received 1 ml of 300 μg/kg body weight of AuNRs. On days 1, 3, 7, and 14 post-treatment, six animals fromeach group were sacrificed and the prostate was dissected and cut into two sections for performing histopathologic and EM study. It hasbeen found that the short term effect of gold nanorods induced pyknotic and apoptotic changes as well as presence of phagocytosis in theprostate tissues. From this study, it could be concluded that gold nanorods have reached prostate tissue; therefore, it could be helpful inupcoming days to establish a concept on the role of gold nanorods in the management of cellular biological behaviors.
ABSTRACT
The study was performed to quantitatively determine ceftiofur residues in different rabbit’s tissues and to estimate thewithdrawal time after intramuscular injection of the drug at a dose of 2.2 mg/kg BW by using high performance liquidchromatography technique. A total of twenty healthy male New Zealand White rabbits were used in this study, the rabbitswere divided into two groups; the first group (n=15) was injected with ceftiofur for five successive days, while the secondgroup (n = 5) remained untreated with any type of medication (control). Liver, kidney, muscle, heart, blood and lungsamples from each rabbit were collected on the 1st, 3rd, 5th and 7th day post treatment. The results indicated a wide spreaddistribution of ceftiofur in the tested tissues, which remained within the detectable level till the 3rd day in the investigatedtissues (heart, muscle and serum), while still detected till the 5th day post treatment in liver, kidney and lung respectively.Therefore, it is recommended that rabbits treated with ceftiofur must not be slaughtered before the end of the fifth day afterthe last dose admistration in order to be safe for human consumption.